Human Sera
Cayman Chemical ButyrylLcarnItInchLRIde 50mg
An inhibitor of Eg5 inhibits the basal and microtubule-stimulated states (IC50s 1000 and 140 nM respectively) selective over nine other human kinesins reversibly inhibits Eg5-driven microtubule sliding velocity (IC50 500 nM) induces cell cycle arrest in HeLa cells (IC50 700 nM) reversibly halts the cell cycle in the mitotic phase inhibits cancer cell growth in the NCI 60 human cancer cell line panel (average GI50 1.3 UM) and in mouse xenograft models
Cayman Chemical NonoIc AcId 100mg
An orally bioavailable inhibitor of L- T- and N-type calcium channels IC50 2.7 nM in guinea pig ventricular cells prevents oxidative stress in vitro and in neural stem cells has antihypertensive effects competitive antagonist at mineralocorticoid receptors
Cayman Chemical TrIcosnoIc AcId 100mg
A major metabolite and degradation product of ciprofloxacin can be created through advanced oxygenation processes of ciprofloxacin in wastewater treatment can be created by chlorination of ciprofloxacin
Cayman Chemical TrImethobenzamIDhydroCLOr 50mg
An antibiotic with diverse biological activites inhibits growth of S. aureus B. subtilis M. luteus M. flavus B. fragilis C. difficile C. perfringens and P. acnes (MICs 0.4-12.5 g/ml) inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay inhibits protein synthesis in CEFs and 3T6 cells (IC50s 7 and 70 M respectively) cytotoxic to human lung carcinoma A549 cells in vitro (IC50 95 nM) increases median survival in P388 leukemia and B16 melanoma mouse tumor models (10 mg/kg per day)
Cayman Chemical DapnsutrIle 100mg
A synthetic vitamin D analog that inhibits cell proliferation and differentiation with reduced calcemic activity compared to that of calcitriol promotes tumor regression in vitro by inducing apoptosis
Cayman Chemical StearoylLcarnItInchLRId 50mg
An aurodox antibiotic has weak activity against S. pneumoniae PARK S. pyogenes and H. influenzae (MICs 16 32 and 64 g/ml respectively in a broth dilutiion assay
Cayman Chemical sorentn 50mg
An Na /K -ATPase inhibitor high affinity for the a1B1 subunit of the Na /K -ATPase inhibits cancer cell growth (GI50 6-58 nM in various human cancer cell lines) induces apoptosis in Jurkat T cells
Cayman Chemical BromadIolon 100mg
A synthetic vitamin D analog that inhibits cell proliferation and differentiation with reduced calcemic activity compared to that of calcitriol promotes tumor regression in vitro by inducing apoptosis
Cayman Chemical 1MyrIstoyl3Oleoylracglyc 50mg
An inhibitor of the Dvl PDZ domain (Kd 240 M for mouse Dvl1 PDZ domain) reduces expression of the Wnt target gene Siamois in Xenopus embryos and inhibits the ability of injected Wnt3A to induce formation of a secondary axis (180 ng) inhibits proliferation of NIH/3T3 fibroblasts restrains their migration in a scratch assay and blocks the accelerating effect of TGF-B on fibroblast migration (10 M) reduces the severity of bleomycin-induced pulmonary fibrosis and expression of a-SMA collagen I TGF-B andBcatenin in lung in mice (5 mg/kg per day for 14 days)
Cayman Chemical PentaacetylquercetIn 100mg
An activator of glucokinase (EC50 42 nM) stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 579 nM) decreases plasma glucose levels in a dose-dependent manner in fasted rats (30 mg/kg)
Cayman Chemical GlucosylceramIdeplnt 100mg
A selective antagonist of σ1 receptors (Ki 0.9 nM in a radioligand binding assay) selective for σ1 receptors with binding affinity values greater than 10000 nM for human recombinant dopamine opioid PCP and serotonin receptors in vitro protects against convulsions and lethality induced by cocaine and reduces cocaine-induced locomotor activity reduces haloperidol- and DTG-induced dystonias in vivo attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain
Cayman Chemical SarsaspogenIn 100mg
A cell-permeant inhibitor of NFAT signaling binds calcineurin (Kd 0.8 UM) preventing it from dephosphorylating NFAT
Cayman Chemical AcetylLcarnItInd3chLRI 50mg
A semisynthetic tetracycline antibiotic more active than tetracycline against 339 strains of anaerobic bacteria (MIC90s 1 and 32 g/ml respectively) active against tetracycline-resistant E. coli S. aureus and E. faecalis strains (MICs 0.06-1 g/ml) active against S. aureus in mice (ED50s 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration respectively)