Human Sera
Cayman Chemical PhosphatIdylethnolamInchI 50mg
A mixture of PEs isolated from egg; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules
Cayman Chemical CItrulInated Hsp70R155 Po 1ea
Immunogen: Peptide from the internal region of human Hsp70 containing a citrulline at residue 155 • Host: Rabbit • Cross Reactivity: (+) Citrullinated Hsp70, Citrullinated GRP78; (-) Hsp70, other citrullinated Hsp proteins • Species Reactivity: (+) Human; other species not tested • Applications: ELISA and WB
Cayman Chemical FlunIsolIde 50mg
A fluorinated corticosteroid receptor agonist; induces reversible pyloric hyalinization in CD-1 mice following oral administration at a dose of 200 μg/kg per day
Cayman Chemical PropentofylIn 50mg
A xanthine derivative and neuroprotective agent; increases NGF production in primary mouse astroglia maximally at 1.11 mM; reduces Aβ42-induced cell death in primary rat hippocampal neurons at 20 UG/ml; reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01, 0.05, and 0.1 mg/kg per minute; inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters
Cayman Chemical MonacylglycRol lpase InHB 50mg
Selectively and reversibly blocks MAGL activity (IC50s = 0.18 and 59 µM for MAGL and FAAH in mouse brain, respectively); does not inhibit ABHD6, ABHD12, CB1, or CB2 receptors (Kis > 10 µM); used to ameliorate disease progression in a mouse model of multiple sclerosis
Cayman Chemical 1R 3S3AmInocyclopentn c 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical R-ZINC3573 50mg
An MRGPRX2 agonist; induces β-arrestin recruitment in a reporter assay using MRGPRX2-expressing HTLA cells and calcium mobilization in LAD 2 mast cells (EC50s = 0.74 and 1 µM, respectively); selective for MRGPRX2 over 21 other GPCRs; induces degranulation of LAD 2 mast cells
Cayman Chemical GInkgonlIc AcId 100mg
An anacardic acid with diverse biological activities; inhibits GPDH (IC50 = 3 μg/ml); inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM); reduces S. mutans biofilm formation (MBIC50 = 4 μg/ml)
Cayman Chemical 2 3Pentylon Isomerhydroch 50mg
A structural isomer of pentylone, having the methylenedioxy group attached at carbons 2 and 3 of the terminal phenyl group; intended for forensic and research applications
Cayman Chemical AlendronATsodIum hydrAT 100mg
An FPP synthase inhibitor (IC50 = 50 nM for the recombinant human enzyme); inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM); reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts at 3 and 10 µM; prevents femoral bone mineral density loss in ovariectomized rats at 5 mg/kg
Cayman Chemical Pralatrexate 100mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical MetaramInoltartrate 50mg
A vasoconstrictor; increases cardiac output, mean arterial pressure, and coronary blood flow and decreases pulse rate in a canine model of cardiogenic shock when administered at a dose of 0.05 mg/kg; increases survival in a canine model of hemorrhagic hypotension; reverses acetoxycycloheximide-induced transient amnesia in a shock avoidance test in rats